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The states of California and Florida present diazepam to condemned inmates to be a pre-execution sedative as portion in their lethal injection program, Even though the point out of California has not executed a prisoner since 2006.

Abuse and misuse of benzodiazepines generally (but not normally) include usage of doses larger than the maximum advisable dosage and typically require concomitant use of other drugs, alcohol, and/or illicit substances, that is linked to an elevated frequency of serious adverse outcomes, together with respiratory melancholy, overdose, or death

stiripentol will decrease the extent or impact of diazepam by affecting hepatic enzyme CYP2C19 metabolism. Modify Therapy/Watch Closely. Consider decreasing the dose of CYP2C19 substrates, if adverse reactions are experienced when administered concomitantly with stiripentol.

lumefantrine will lessen the extent or effect of diazepam by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Observe.

eslicarbazepine acetate will increase the level or impact of diazepam by influencing hepatic enzyme CYP2C19 metabolism. Use Caution/Keep track of.

diltiazem will increase the stage or impact of diazepam by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Check.

cyclosporine will raise the degree or impact of diazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.

If this isn't feasible, give drug into tubing of a flowing IV Option as near as possible to vein insertion

When you are prescribed diazepam for a lot more than 4 months, your dose might be lessened steadily to stop withdrawal signs.

Use Warning/Monitor. Ethinyl estradiol might inhibit the clearance of benzodiazepines that go through oxidation, therefore increasing serum concentrations of concomitantly administered benzodiazepines.

diazepam will increase levels of lomitapide by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Watch. Lomitapide dose shouldn't exceed 30 mg/day.

diazepam and daridorexant the two increase sedation. Modify Therapy/Watch Carefully. Coadministration will increase chance of CNS melancholy, which can lead to additive impairment of psychomotor performance and cause more info daytime impairment.

griseofulvin will decrease the level or result of diazepam by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep an eye on.

Diazepam inhibits acetylcholine release in mouse hippocampal synaptosomes. This continues to be found by measuring sodium-dependent significant-affinity choline uptake in mouse brain cells in vitro, just after pretreatment on the mice with diazepam in vivo. This will Participate in a job in describing diazepam's anticonvulsant properties.[103]

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